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Liver condition, moderate or average—Use with warning. The effects may be improved thanks to slower removing in the medication from the body.Fenobarbital uzet istovremeno može dovesti do aditivnog efekta na CNS. Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim i ubrzava metabolizam diazepam

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